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Journal of Biomedical Optics • Open Access

Oblique incidence reflectometry: optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system

Paper Abstract

A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and <italic<in vivo</italic< mouse colon, verifying the endoscope’s capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.

Paper Details

Date Published: 3 June 2014
PDF: 8 pages
J. Biomed. Opt. 19(6) 067002 doi: 10.1117/1.JBO.19.6.067002
Published in: Journal of Biomedical Optics Volume 19, Issue 6
Show Author Affiliations
R. Andrew Wall, College of Optical Sciences, The Univ. of Arizona (United States)
Jennifer K. Barton, The Univ. of Arizona (United States)


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