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Journal of Biomedical Optics

Identification of dirty necrosis in colorectal carcinoma based on multiphoton microscopy
Author(s): Lianhuang Li; Weizhong Jiang; Yinghong Yang; Zhifen Chen; Changyin Feng; Hongsheng Li; Guoxian Guan; Jianxin Chen
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Paper Abstract

Dirty necrosis within glandular lumina is often considered as a characteristic of colorectal carcinomas (CRCs) that is a diagnostically useful feature of CRCs with DNA microsatellite instability (MSI). Multiphoton microscopy (MPM), which is based on the second-harmonic generation and two-photon excited fluorescence signals, was used to identify dirty necrosis. Our results demonstrated that MPM has the ability to exhibit the microstructure of dirty necrosis and the signal intensity as well as an emission spectrum that can help to differentiate dirty necrosis from cancer cells. These findings indicate that MPM may be helpful in distinguishing MSI colorectal carcinoma via the identification of dirty necrosis.

Paper Details

Date Published: 26 June 2014
PDF: 5 pages
J. Biomed. Opt. 19(6) 066008 doi: 10.1117/1.JBO.19.6.066008
Published in: Journal of Biomedical Optics Volume 19, Issue 6
Show Author Affiliations
Lianhuang Li, Fujian Normal Univ. (China)
Weizhong Jiang, Fujian Medical Univ. (China)
Yinghong Yang, Fujian Medical Univ. (China)
Zhifen Chen, Fujian Medical Univ. (China)
Changyin Feng, Fujian Medical Univ. (China)
Hongsheng Li, Fujian Normal Univ. (China)
Guoxian Guan, Fujian Medical Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)

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