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Journal of Biomedical Optics • Open Access

Mapping optical fluence variations in highly scattering media by measuring ultrasonically modulated backscattered light
Author(s): Altaf Hussain; Khalid Daoudi; Erwin Hondebrink; Wiendelt Steenbergen

Paper Abstract

Knowledge of the local optical fluence in biological tissue is of fundamental importance for biomedical optical techniques to achieve quantification. We report a method to noninvasively measure the local optical fluence in optically inhomogeneous scattering media. The concept is based on two aspects: the local tagging of light using ultrasonic modulation and the photon path reversibility principle. Our method has advantages over known computational-based fluence mapping techniques, for its purely experimental nature and without the requirement of prior knowledge of the optical properties of the medium. We provide a theoretical formalism and validation of the method with experiments in tissue-like phantoms. Further, we combine our method with photoacoustic imaging and compensate the photoacoustic signals for fluence variations in optically inhomogeneous media.

Paper Details

Date Published: 2 June 2014
PDF: 6 pages
J. Biomed. Opt. 19(6) 066002 doi: 10.1117/1.JBO.19.6.066002
Published in: Journal of Biomedical Optics Volume 19, Issue 6
Show Author Affiliations
Altaf Hussain, Univ. Twente (Netherlands)
Khalid Daoudi, Univ. Twente (Netherlands)
Erwin Hondebrink, Univ. Twente (Netherlands)
Wiendelt Steenbergen, Univ. Twente (Netherlands)

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