Share Email Print
cover

Journal of Biomedical Optics

Coupled forward-adjoint Monte Carlo simulation of spatial-angular light fields to determine optical sensitivity in turbid media
Author(s): Adam R. Gardner; Carole K. Hayakawa; Vasan Venugopalan
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We present a coupled forward-adjoint Monte Carlo (cFAMC) method to determine the spatially resolved sensitivity distributions produced by optical interrogation of three-dimensional (3-D) tissue volumes. We develop a general computational framework that computes the spatial and angular distributions of the forward-adjoint light fields to provide accurate computations in mesoscopic tissue volumes. We provide full computational details of the cFAMC method and provide results for low- and high-scattering tissues probed using a single pair of optical fibers. We examine the effects of source-detector separation and orientation on the sensitivity distributions and consider how the degree of angular discretization used in the 3-D tissue model impacts the accuracy of the resulting absorption sensitivity profiles. We discuss the value of such computations for optical imaging and the design of optical measurements.

Paper Details

Date Published: 27 June 2014
PDF: 13 pages
J. Biomed. Opt. 19(6) 065003 doi: 10.1117/1.JBO.19.6.065003
Published in: Journal of Biomedical Optics Volume 19, Issue 6
Show Author Affiliations
Adam R. Gardner, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Carole K. Hayakawa, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Vasan Venugopalan, Beckman Laser Institute and Medical Clinic (United States)
Univ. of Callifornia, Irvine (United States)


© SPIE. Terms of Use
Back to Top