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Journal of Biomedical Optics

Ear swelling test by using laser speckle imaging with a long exposure time
Author(s): Vyacheslav Kalchenko; Yuri Kuznetsov; Dina Preise; Igor V. Meglinski; Alon Harmelin
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Paper Abstract

Laser speckle imaging with long exposure time has been applied noninvasively to visualize the immediate reaction of cutaneous vessels in mice in response to a known primary irritant and potential allergen—methyl salicylate. The compound has been used topically on the surface of the pinna and the reaction of the vascular network was examined. We demonstrate that irritant-induced acute vascular reaction can be effectively and accurately detected by laser speckle imaging technique. The current approach holds a great promise for application in routine screening of the cutaneous vascular response induced by contact agents, screenings of mouse ear swelling test, and testing the allergenic potential of new synthetic materials and healthcare pharmaceutical products.

Paper Details

Date Published: 26 June 2014
PDF: 3 pages
J. Biomed. Opt. 19(6) 060502 doi: 10.1117/1.JBO.19.6.060502
Published in: Journal of Biomedical Optics Volume 19, Issue 6
Show Author Affiliations
Vyacheslav Kalchenko, Weizmann Institute of Science (Israel)
Yuri Kuznetsov, Weizmann Institute of Science (Israel)
Dina Preise, Weizmann Institute of Science (Israel)
Igor V. Meglinski, Univ. of Otago (New Zealand)
Alon Harmelin, Weizmann Institute of Science (Israel)


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