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Journal of Biomedical Optics • Open Access

Initial results of finger imaging using photoacoustic computed tomography
Author(s): Peter van Es; Samir K. Biswas; Hein J. Bernelot Moens; Wiendelt Steenbergen; Srirang Manohar

Paper Abstract

We present a photoacoustic computed tomography investigation on a healthy human finger, to image blood vessels with a focus on vascularity across the interphalangeal joints. The cross-sectional images were acquired using an imager specifically developed for this purpose. The images show rich detail of the digital blood vessels with diameters between 100 <italic<μ</italic<m and 1.5 mm in various orientations and at various depths. Different vascular layers in the skin including the subpapillary plexus could also be visualized. Acoustic reflections on the finger bone of photoacoustic signals from skin were visible in sequential slice images along the finger except at the location of the joint gaps. Not unexpectedly, the healthy synovial membrane at the joint gaps was not detected due to its small size and normal vascularization. Future research will concentrate on studying digits afflicted with rheumatoid arthritis to detect the inflamed synovium with its heightened vascularization, whose characteristics are potential markers for disease activity.

Paper Details

Date Published: 2 June 2014
PDF: 3 pages
J. Biomed. Opt. 19(6) 060501 doi: 10.1117/1.JBO.19.6.060501
Published in: Journal of Biomedical Optics Volume 19, Issue 6
Show Author Affiliations
Peter van Es, Univ. Twente (Netherlands)
Samir K. Biswas, Univ. Twente (Netherlands)
Hein J. Bernelot Moens, Ziekenhuis Groep Twente (Netherlands)
Wiendelt Steenbergen, Univ. Twente (Netherlands)
Srirang Manohar, Univ. Twente (Netherlands)

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