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Journal of Biomedical Optics • Open Access

Towards clinical use of a laser-induced microjet system aimed at reliable and safe drug delivery
Author(s): Hun-jae Jang; Hyeonju Yu; Seonggeun Lee; Eugene Hur; Yoonkwan Kim; Seol-Hoon Lee; Naegyu Kang; Jack J. Yoh

Paper Abstract

An Er:YAG laser with 2940-nm wavelength and 250-μs pulse duration is used to generate a microjet that is ejected at ∼50  m/s in air. The strength of the microjet depends on the bubble dynamics from the beam–water interaction within the driving chamber as well as the discharging of the drug solution underneath the elastic membrane that separates the drug from the driving liquid. The jet characteristics, such as velocity, volume, and level of atomization, are obtained by high-speed camera images taken at 42,000 fps. The enhancements in jet volume (dosage) and repeated jet generation, which are aimed at making the injector suitable for general clinical applications, are achieved. The generation of repeated microjets is achieved with the help of a stepping motor that provides a uniform pressure within the drug reservoir before an ejection occurs through a micro nozzle. Also, two types of human growth hormones are used for monitoring any potential thermal damage to the drug solution due to a repeated laser ablation when driving the microjet. We provide strong evidence to support that the drugs, as they are injected to porcine skins, are free of the damage associated with the present delivery method.

Paper Details

Date Published: 21 May 2014
PDF: 6 pages
J. Biomed. Opt. 19(5) 058001 doi: 10.1117/1.JBO.19.5.058001
Published in: Journal of Biomedical Optics Volume 19, Issue 5
Show Author Affiliations
Hun-jae Jang, Seoul National Univ. (Korea, Republic of)
Hyeonju Yu, Seoul National Univ. (Korea, Republic of)
Seonggeun Lee, B & B Systems (Korea, Republic of)
Eugene Hur, LG Household & Health Care R & D Ctr. (Korea, Republic of)
Yoonkwan Kim, LG Household & Health Care R & D Ctr. (Korea, Republic of)
Seol-Hoon Lee, LG Household & Health Care R & D Ctr. (Korea, Republic of)
Naegyu Kang, LG Household & Health Care R & D Ctr. (Korea, Republic of)
Jack J. Yoh, Seoul National Univ. (Korea, Republic of)

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