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Journal of Biomedical Optics

Noninvasive assessment of the risk of tobacco abuse in oral mucosa using fluorescence spectroscopy: a clinical approach
Author(s): Shaiju S. Nazeer; Rajashekharan Asish; Chandrashekharan Venugopal; Balan Anita; Arun Kumar Gupta; Ramapurath S. Jayasree
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Paper Abstract

Tobacco abuse and alcoholism cause cancer, emphysema, and heart disease, which contribute to high death rates, globally. Society pays a significant cost for these habits whose first demonstration in many cases is in the oral cavity. Oral cavity disorders are highly curable if a screening procedure is available to diagnose them in the earliest stages. The aim of the study is to identify the severity of tobacco abuse, in oral cavity, as reflected by the emission from endogenous fluorophores and the chromophore hemoglobin. A group who had no tobacco habits and another with a history of tobacco abuse were included in this study. To compare the results with a pathological condition, a group of leukoplakia patients were also included. Emission from porphyrin and the spectral filtering modulation effect of hemoglobin were collected from different sites. Multivariate analysis strengthened the spectral features with a sensitivity of 60% to 100% and a specificity of 76% to 100% for the discrimination. Total hemoglobin and porphyrin levels of habitués and leukoplakia groups were comparable, indicating the alarming situation about the risk of tobacco abuse. Results prove that fluorescence spectroscopy along with multivariate analysis is an effective noninvasive tool for the early diagnosis of pathological changes due to tobacco abuse.

Paper Details

Date Published: 28 May 2014
PDF: 11 pages
J. Biomed. Opt. 19(5) 057013 doi: 10.1117/1.JBO.19.5.057013
Published in: Journal of Biomedical Optics Volume 19, Issue 5
Show Author Affiliations
Shaiju S. Nazeer, Sree Chitra Tirunal Institute for Medical Sciences & Technology (India)
Mar Ivanios College (India)
Rajashekharan Asish, Government Dental College, Thiruvananthapuram (India)
Chandrashekharan Venugopal, Government Dental College, Thiruvananthapuram (India)
General Hospital (India)
Balan Anita, Government Dental College, Thiruvananthapuram (India)
Arun Kumar Gupta, Sree Chitra Tirunal Institute for Medical Sciences and Technology (India)
National Institute of Mental Health and Neuro Sciences (India)
Ramapurath S. Jayasree, Sree Chitra Tirunal Institute for Medical Sciences & Technology (India)

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