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Journal of Biomedical Optics • Open Access

Cervical cancer detection by time-resolved spectra of blood components
Author(s): Rudran Kalaivani; Vadivel Masilamani; Mohamad Saleh AlSalhi; Sandhanasamy Devanesan; P. Ramamurthy; Siddanna R. Palled; K. M. Ganesh

Paper Abstract

Fluorescence spectral techniques are very sensitive, and hence they are gaining importance in cancer detection. The biomarkers indicative of cancer could be identified and quantified by spectral or time domain fluorescence spectroscopy. The results of an investigation of time-resolved spectra of cellular components of blood obtained from cervical cancer patients and normal controls are given. The cancer indicative biomarker in this paper is porphyrin; it has a fluorescence decay time of 60% more in samples of cancer patients than those of normal controls. Based on such measurements, a randomized set comprising samples from cancer patients and controls (N=27 in total) could be classified with sensitivity (92%) and specificity (86%).

Paper Details

Date Published: 22 May 2014
PDF: 5 pages
J. Biomed. Opt. 19(5) 057011 doi: 10.1117/1.JBO.19.5.057011
Published in: Journal of Biomedical Optics Volume 19, Issue 5
Show Author Affiliations
Rudran Kalaivani, King Saud Univ. (Saudi Arabia)
Univ. of Madras (India)
Vadivel Masilamani, King Saud Univ. (Saudi Arabia)
Mohamad Saleh AlSalhi, King Saud Univ. (Saudi Arabia)
Sandhanasamy Devanesan, King Saud Univ. (Saudi Arabia)
P. Ramamurthy, Univ. of Madras Taramani Campus (India)
Siddanna R. Palled, Kidwai Memorial Institute of Oncology (India)
K. M. Ganesh, Kidwai Memorial Institute of Oncology (India)

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