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Journal of Biomedical Optics

Monitoring of the action of drugs in melanoma cells by dynamic laser speckle
Author(s): Rolando J. González-Peña; Roberto A. Braga; Rosa M. Cibrián; Rosario Salvador-Palmer; Rosario Gil-Benso; Teresa San Miguel
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Paper Abstract

This work presents the development of a protocol based on the dynamic laser speckle designed to monitor the reaction of cancer cells of line MEL-RC08 to the application of the drug Colcemid in two different concentrations: 0.2 and 0.4  μg/mL . The protocol was designed using the forward scattering approach with an He-Ne laser of 632.8 nm illuminating the samples, a control, and two variations of Colcemid, being monitored along 8 h. The data were analyzed numerically in the time and in the frequency domain, and the results presented the ability of the technique to monitor the action of the drug, particularly Colcemid (0.4  μg/mL ).

Paper Details

Date Published: 14 May 2014
PDF: 5 pages
J. Biomed. Opt. 19(5) 057008 doi: 10.1117/1.JBO.19.5.057008
Published in: Journal of Biomedical Optics Volume 19, Issue 5
Show Author Affiliations
Rolando J. González-Peña, Univ. de València (Spain)
Roberto A. Braga, Univ. Federal de Lavras (Brazil)
Rosa M. Cibrián, Univ. de València (Spain)
Rosario Salvador-Palmer, Univ. de València (Spain)
Rosario Gil-Benso, Univ. de València (Spain)
Teresa San Miguel, Univ. de València (Spain)

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