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Journal of Biomedical Optics • Open Access

Detection of circulating tumor cells using targeted surface-enhanced Raman scattering nanoparticles and magnetic enrichment
Author(s): Wei Shi; Robert J. Paproski; Ronald B. Moore; Roger Zemp

Paper Abstract

While more than 90% of cancer deaths are due to metastases, our ability to detect circulating tumor cells (CTCs) is limited by low numbers of these cells in the blood and factors confounding specificity of detection. We propose a magnetic enrichment and detection technique for detecting CTCs with high specificity. We targeted both magnetic and surface-enhanced Raman scattering (SERS) nanoparticles to cancer cells. Only cells that are dual-labeled with both kinds of nanoparticles demonstrate an increasing SERS signal over time due to magnetic trapping.

Paper Details

Date Published: 23 May 2014
PDF: 8 pages
J. Biomed. Opt. 19(5) 056014 doi: 10.1117/1.JBO.19.5.056014
Published in: Journal of Biomedical Optics Volume 19, Issue 5
Show Author Affiliations
Wei Shi, Univ. of Alberta (Canada)
Robert J. Paproski, Univ. of Alberta (Canada)
Ronald B. Moore, Univ. of Alberta (Canada)
Roger Zemp, Univ. of Alberta (Canada)


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