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Journal of Biomedical Optics

Modified forward model for eliminating the time-varying impact in fluorescence molecular tomography
Author(s): Wei He; Guanglei Zhang; Huangsheng Pu; Fei Liu; Xu Cao; Jianwen Luo; Jing Bai
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Paper Abstract

In conventional fluorescence molecular tomography, the distribution of fluorescent contrast agents is reconstructed with the assumption of constant concentration during data acquisition for each image frame. However, the concentration of fluorescent contrast target is usually time-varying in experiments or <italic<in-vivo</italic< studies. In this case, the reconstruction methods cannot be directly applied to the fluorescence measurements without considering the time-varying effects of concentration. We propose a modified forward model by dividing the fluorescence yield distribution into two parts: one is a constant representing the spatial distribution of the fluorescent target and the other is an impact factor representing the effects of the concentration change and other possible factors. By extracting spatial distribution information from the reconstruction result, the location and volume of the fluorescent target can be obtained accurately. Both simulation and phantom experiments are carried out and the results indicate that, by using the modified forward model, the quality of reconstruction could be significantly improved in terms of accurate localization and strong anti-noise ability.

Paper Details

Date Published: 22 May 2014
PDF: 8 pages
J. Biomed. Opt. 19(5) 056012 doi: 10.1117/1.JBO.19.5.056012
Published in: Journal of Biomedical Optics Volume 19, Issue 5
Show Author Affiliations
Wei He, Tsinghua Univ. School of Medicine (China)
Guanglei Zhang, Tsinghua Univ. School of Medicine (China)
Huangsheng Pu, Tsinghua Univ. School of Medicine (China)
Fei Liu, Tsinghua Univ. School of Medicine (China)
Xu Cao, Xidian Univ. (China)
Jianwen Luo, Tsinghua Univ. School of Medicine (China)
Jing Bai, Tsinghua Univ. School of Medicine (China)

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