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Journal of Biomedical Optics

Aptamer-conjugated gold nanorod for photothermal ablation of epidermal growth factor receptor-overexpressed epithelial cancer
Author(s): Jihye Choi; Yeonji Park; Eun Bi Choi; Hyun-Ouk Kim; Dong Joo Kim; Yoochan Hong; Sung-Ho Ryu; Jung Hwan Lee; Jin-Suck Suh; Jaemoon Yang; Yong-Min Huh; Seungjoo Haam
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Paper Abstract

Biomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal growth factor receptor aptamer (Apt EGFR )-conjugated polyethylene glycol (PEG) layted gold nanorods (Apt EGFR -PGNRs). The cetyltrimethylammonium bromide bilayer on GNRs was replaced with heterobifunctional PEG (COOH-PEG-SH) not only to serve as a biocompatible stabilizer and but also to conjugate Apt EGFR . Subsequently, to direct photothermal therapy agent toward epithelial cancer cells, the carboxylated PEGylated GNRs (PGNRs) were further functionalized with Apt EGFR using carbodiimide chemistry. Then, to assess the potential as biomarker-specific photothermal therapy agent of synthesized Apt EGFR -PGNRs, the optical properties, biocompatibility, colloidal stability, binding affinity, and epicellial cancer cell killing efficacy in vitro/in vivo under near-infrared laser irradiation were investigated. As a result, Apt EGFR -PGNRs exhibit excellent tumor targeting ability and feasibility of effective photothermal ablation cancer therapy.

Paper Details

Date Published: 2 December 2013
PDF: 7 pages
J. Biomed. Opt. 19(5) 051203 doi: 10.1117/1.JBO.19.5.051203
Published in: Journal of Biomedical Optics Volume 19, Issue 5
Show Author Affiliations
Jihye Choi, Yonsei Univ. (Korea, Republic of)
Yeonji Park, Yonsei Univ. College of Medicine (Korea, Republic of)
Eun Bi Choi, Yonsei Univ. (Korea, Republic of)
Hyun-Ouk Kim, Yonsei Univ. (China)
Dong Joo Kim, Yonsei Univ. (Korea, Republic of)
Yoochan Hong, Yonsei Univ. (Korea, Republic of)
Sung-Ho Ryu, Pohang Univ. of Science and Technology (Korea, Republic of)
Jung Hwan Lee, Pohang Univ. of Science and Technology (Korea, Republic of)
Jin-Suck Suh, Yonsei Univ. College of Medicine (Korea, Republic of)
Jaemoon Yang, Yonsei Univ. College of Medicine (Korea, Republic of)
Yong-Min Huh, Yonsei Univ. College of Medicine (Korea, Republic of)
Seungjoo Haam, Yonsei Univ. (Korea, Republic of)

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