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Journal of Biomedical Optics • Open Access

Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging
Author(s): Ming Li; Jing Lu; Ji Qi; Fusheng Zhao; Jianbo Zeng; Jorn Chi-Chung Yu; Wei-Chuan Shih

Paper Abstract

We report stamping surface-enhanced Raman spectroscopy (S-SERS) for label-free, multiplexed, molecular sensing and large-area, high-resolution molecular imaging on a flexible, nonplasmonic surface without solution-phase molecule transfer. In this technique, a polydimethylsiloxane (PDMS) thin film and nanoporous gold disk SERS substrate play the roles as molecule carrier and Raman signal enhancer, respectively. After stamping the SERS substrate onto the PDMS film, SERS measurements can be directly taken from the “sandwiched” target molecules. The performance of S-SERS is evaluated by the detection of Rhodamine 6G, urea, and its mixture with acetaminophen, in a physiologically relevant concentration range, along with the corresponding SERS spectroscopic maps. S-SERS features simple sample preparation, low cost, and high reproducibility, which could lead to SERS-based sensing and imaging for point-of-care and forensics applications.

Paper Details

Date Published: 7 May 2014
PDF: 3 pages
J. Biomed. Opt. 19(5) 050501 doi: 10.1117/1.JBO.19.5.050501
Published in: Journal of Biomedical Optics Volume 19, Issue 5
Show Author Affiliations
Ming Li, Univ. of Houston (United States)
Jing Lu, Univ. of Houston (United States)
Ji Qi, Univ. of Houston (United States)
Fusheng Zhao, Univ. of Houston (United States)
Jianbo Zeng, Univ. of Houston (United States)
Jorn Chi-Chung Yu, Sam Houston State Univ. (United States)
Wei-Chuan Shih, Univ. of Houston (United States)

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