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Journal of Biomedical Optics

Double-pass Mach–Zehnder fiber interferometer pH sensor
Author(s): Zhi Qiang Tou; Chi Chiu Chan; Jesmond Hong; Shermaine Png; Khay Ming Tan Eddie; Terence Aik Huang Tan
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Paper Abstract

A biocompatible fiber-optic pH sensor based on a unique double-pass Mach–Zehnder interferometer is proposed. pH responsive poly(2-hydroxyethyl methacrylate-co-2-(dimethylamino)ethyl methacrylate) hydrogel coating on the fiber swells/deswells in response to local pH, leading to refractive index changes that manifest as shifting of interference dips in the optical spectrum. The pH sensor is tested in spiked phosphate buffer saline and demonstrates high sensitivity of 1.71  nm/pH , pH 0.004 limit of detection with good responsiveness, repeatability, and stability. The proposed sensor has been successfully applied in monitoring the media pH in cell culture experiments to investigate the relationship between pH and cancer cell growth.

Paper Details

Date Published: 10 April 2014
PDF: 8 pages
J. Biomed. Opt. 19(4) 047002 doi: 10.1117/1.JBO.19.4.047002
Published in: Journal of Biomedical Optics Volume 19, Issue 4
Show Author Affiliations
Zhi Qiang Tou, Nanyang Technological Univ. (Singapore)
Chi Chiu Chan, Nanyang Technological Univ. (Singapore)
Jesmond Hong, Nanyang Technological Univ. (Singapore)
Shermaine Png, Nanyang Technological Univ. (Singapore)
Khay Ming Tan Eddie, EINST Technology Pte Ltd. (Singapore)
Terence Aik Huang Tan, Nanyang Technological Univ. (Singapore)

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