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Journal of Biomedical Optics • Open Access

Monitoring the blood coagulation process under various flow conditions with optical coherence tomography
Author(s): Xiangqun Xu; Jinhai Geng; Xiangshuai Teng

Paper Abstract

Our previous work demonstrated that an optical coherence tomography (OCT) technique was able to characterize the whole blood coagulation process. The 1/e light penetration depth (d1/e) derived from the profiles of reflectance versus depth was developed for detecting the whole blood coagulation process in static state. To consider the effect of blood flow, in the present study, d1/e versus time from the coagulating porcine blood circulated in a mock flow loop with various steady laminar flows at mean flow speed in the range from 5 to 25  mm/s. The variation of d1/e was used to represent the change of blood properties during coagulation in different hematocrits (HCT) ranging from 25% to 55%, velocities from 5 to 25  mm/s, and tubing sizes from 0.9 to 2 mm. The results showed that there were positive correlations between coagulation time (tc) and HCT, velocity, and tubing size, respectively. In addition, the coagulation rate (Sr) was decreased with the increase of HCT, velocity, and tubing size. This study testified that HCT, flow velocity, and tubing size were substantial factors affecting the backscattering properties during flowing blood coagulation. Furthermore, OCT has the potential to represent the process of flowing blood coagulation with proper parameters.

Paper Details

Date Published: 29 April 2014
PDF: 7 pages
J. Biomed. Opt. 19(4) 046021 doi: 10.1117/1.JBO.19.4.046021
Published in: Journal of Biomedical Optics Volume 19, Issue 4
Show Author Affiliations
Xiangqun Xu, Zhejiang Sci-Tech Univ. (China)
Jinhai Geng, Zhejiang Sci-Tech Univ. (China)
Xiangshuai Teng, Zhejiang Sci-Tech Univ. (China)

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