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Journal of Biomedical Optics

Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples
Author(s): Wenfeng Wang; Lee Guan Lim; Supriya Srivastava; Jimmy So Bok Yan; Asim Shabbir; Quan Liu
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Paper Abstract

Multispectral Mueller matrix imaging was performed over a spectral range from 470 to 632 nm on 4-μm unstained gastric tissue sections. A complete set of polarization parameters was derived. The combination of linear depolarization and linear retardance yields the highest accuracy in sample classification. When the depolarization of linearly polarized light due to scattering is independent of the orientation angle of the incident linear polarization vector, the derivation of linear polarization properties will require only 3×3 Mueller matrix, which would significantly reduce the complexity of the polarimetry imaging system. When additional parameters are needed to complement the two linear polarization parameters, retardance, circular depolarization, and depolarization can be included in classification in the order of preference. However, these additional parameters would require the measurement of 4×4 Mueller matrix. In addition, it appears that wavelength is not a critical factor in terms of classification accuracy for thin tissue sections in this study.

Paper Details

Date Published: 28 April 2014
PDF: 10 pages
J. Biomed. Opt. 19(4) 046020 doi: 10.1117/1.JBO.19.4.046020
Published in: Journal of Biomedical Optics Volume 19, Issue 4
Show Author Affiliations
Wenfeng Wang, Nanyang Technological Univ. (Singapore)
Lee Guan Lim, National Univ. Health System (Singapore)
Supriya Srivastava, National Univ. of Singapore (Singapore)
Jimmy So Bok Yan, National Univ. of Singapore (Singapore)
Asim Shabbir, National Univ. of Singapore (Singapore)
Quan Liu, Nanyang Technological Univ. (Singapore)

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