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Journal of Biomedical Optics

Video-rate optical flow corrected intraoperative functional fluorescence imaging
Author(s): Maximilian W. Koch; Jürgen Glatz; Vladimir Ermolayev; Elisabeth G. de Vries; Gooitzen M. van Dam; Karl-Hans Englmeier; Vasilis Ntziachristos
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Paper Abstract

Intraoperative fluorescence molecular imaging based on targeted fluorescence agents is an emerging approach to improve surgical and endoscopic imaging and guidance. Short exposure times per frame and implementation at video rates are necessary to provide continuous feedback to the physician and avoid motion artifacts. However, fast imaging implementations also limit the sensitivity of fluorescence detection. To improve on detection sensitivity in video rate fluorescence imaging, we considered herein an optical flow technique applied to texture-rich color images. This allows the effective accumulation of fluorescence signals over longer, virtual exposure times. The proposed correction scheme is shown to improve signal-to-noise ratios both in phantom experiments and <italic<in vivo</italic< tissue imaging.

Paper Details

Date Published: 21 April 2014
PDF: 9 pages
J. Biomed. Opt. 19(4) 046012 doi: 10.1117/1.JBO.19.4.046012
Published in: Journal of Biomedical Optics Volume 19, Issue 4
Show Author Affiliations
Maximilian W. Koch, Technische Univ. München (Germany)
Jürgen Glatz, Technische Univ. München (Germany)
Vladimir Ermolayev, Technische Univ. München (Germany)
Elisabeth G. de Vries, Univ. Medical Ctr. Groningen (The Netherlands)
Gooitzen M. van Dam, Univ. Medical Ctr. Groningen (Netherlands)
Karl-Hans Englmeier, Technische Univ. München (Germany)
Helmholtz Zentrum München GmbH (Germany)
Vasilis Ntziachristos, Technische Univ. München (Germany)

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