Share Email Print

Journal of Biomedical Optics

Fast vascular component of cortical spreading depression revealed in rats by blood pulsation imaging
Author(s): Victor Teplov; Artem Shatillo; Ervin Nippolainen; Olli Gröhn; Rashid Giniatullin; Alexei A. Kamshilin
Format Member Price Non-Member Price
PDF $20.00 $25.00

Paper Abstract

Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of neurons and glia and has a less characterized vascular component. CSD is a commonly used phenomenon to test new methods of live brain imaging. Application of a blood pulsations imaging (BPI) technique to study of CSD induced with high-potassium solution in rat cortex allowed us to visualize for the first time the novel vascular component of a CSD wave. In our study, this wave component propagated in the limited part of the cortex along the bow-shaped trajectory in sharp contrast with concentric development of CSD measured by concurrently applied optical intrinsic signal (OIS) imaging technique. It was associated with a significant increase of the blood pulsations amplitude (BPA), started with a delay of 20 to 90 s comparing to signal measured with OIS, and propagated 40% faster than OIS signal. These findings suggest that the BPA and slower change of the cerebral blood volume are not directly related to each other even though both characterize the same vascular system. Our study indicates that the BPI technique could be used for characterization of the new pulsatile vascular component of CSDs in animal models of migraine, stroke, and brain trauma.

Paper Details

Date Published: 11 April 2014
PDF: 10 pages
J. Biomed. Opt. 19(4) 046011 doi: 10.1117/1.JBO.19.4.046011
Published in: Journal of Biomedical Optics Volume 19, Issue 4
Show Author Affiliations
Victor Teplov, Univ. of Eastern Finland (Finland)
Artem Shatillo, Univ. of Eastern Finland (Finland)
Ervin Nippolainen, Univ. of Eastern Finland (Finland)
Olli Gröhn, Univ. of Eastern Finland (Finland)
Rashid Giniatullin, Univ. of Eastern Finland (Finland)
Kazan Federal Univ. (Russian Federation)
Alexei A. Kamshilin, Univ. of Eastern Finland (Finland)

© SPIE. Terms of Use
Back to Top