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Journal of Biomedical Optics

Numerical simulation of x-ray luminescence optical tomography for small-animal imaging
Author(s): Changqing Li; Arnulfo Martinez-Davalos; Simon R. Cherry
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Paper Abstract

X-ray luminescence optical tomography (XLOT) is an emerging hybrid imaging modality in which x-ray excitable particles (phosphor particles) emit optical photons when stimulated with a collimated x-ray beam. XLOT can potentially combine the high sensitivity of optical imaging with the high spatial resolution of x-ray imaging. For reconstruction of XLOT data, we compared two reconstruction algorithms, conventional filtered backprojection (FBP) and a new algorithm, x-ray luminescence optical tomography with excitation priors (XLOT-EP), in which photon propagation is modeled with the diffusion equation and the x-ray beam positions are used as reconstruction priors. Numerical simulations based on dose calculations were used to validate the proposed XLOT imaging system and the reconstruction algorithms. Simulation results showed nanoparticle concentrations reconstructed with XLOT-EP are much less dependent on scan depth than those obtained with FBP. Measurements at just two orthogonal projections are sufficient for XLOT-EP to reconstruct an XLOT image for simple source distributions. The heterogeneity of x-ray energy deposition is included in the XLOT-EP reconstruction and improves the reconstruction accuracy, suggesting that there is a need to calculate the x-ray energy distribution for experimental XLOT imaging.

Paper Details

Date Published: 2 April 2014
PDF: 11 pages
J. Biomed. Opt. 19(4) 046002 doi: 10.1117/1.JBO.19.4.046002
Published in: Journal of Biomedical Optics Volume 19, Issue 4
Show Author Affiliations
Changqing Li, Univ. of California, Merced (United States)
Arnulfo Martinez-Davalos, Univ. Nacional Autónoma de México (Mexico)
Simon R. Cherry, Univ. of California, Davis (United States)


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