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Journal of Biomedical Optics

High-purity separation of cancer cells by optically induced dielectrophoresis
Author(s): Hsiu-Hsiang Chen; Mai-Wei Lin; Wan-Ting Tien; Chin-Pen Lai; Kuo-Yao Weng; Ching-Huai Ko; Chun-Chuan Lin; Jyh-Chern Chen; Kuo-Tung Tiao; Tse-Ching Chen; Shin-Cheh Chen; Ta-Sen Yeh; Chieh-Fang Cheng
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Paper Abstract

Detecting and concentrating cancer cells in peripheral blood is of great importance for cancer diagnosis and prognosis. Optically induced dielectrophoresis (ODEP) can achieve high resolution and low optical intensities, and the electrode pattern can be dynamically changed by varied light patterns. By changing the projected light pattern, it is demonstrated to separate high-purity gastric cancer cell lines. Traditionally, the purity of cancer cell isolation by negative selection is 0.9% to 10%; by positive selection it is 50% to 62%. An ODEP technology is proposed to enhance the purity of cancer cell isolation to about 77%.

Paper Details

Date Published: 10 April 2014
PDF: 10 pages
J. Biomed. Opt. 19(4) 045002 doi: 10.1117/1.JBO.19.4.045002
Published in: Journal of Biomedical Optics Volume 19, Issue 4
Show Author Affiliations
Hsiu-Hsiang Chen, Industrial Technology Research Institute (Taiwan)
Mai-Wei Lin, Industrial Technology Research Institute (Taiwan)
Wan-Ting Tien, Industrial Technology Research Institute (Taiwan)
Chin-Pen Lai, Industrial Technology Research Institute (Taiwan)
Kuo-Yao Weng, Industrial Technology Research Institute (Taiwan)
Ching-Huai Ko, Industrial Technology Research Institute (Taiwan)
Chun-Chuan Lin, Industrial Technology Research Institute (Taiwan)
Jyh-Chern Chen, Industrial Technology Research Institute (Taiwan)
Kuo-Tung Tiao, Industrial Technology Research Institute (Taiwan)
Tse-Ching Chen, Chang Gung Univ. (Taiwan)
Shin-Cheh Chen, Chang Gung Univ. (Taiwan)
Ta-Sen Yeh, Chang Gung Univ. (Taiwan)
Chieh-Fang Cheng, Industrial Technology Research Institute (Taiwan)


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