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Journal of Biomedical Optics

Tryptophan as the fingerprint for distinguishing aggressiveness among breast cancer cell lines using native fluorescence spectroscopy
Author(s): Lin Zhang; Yang Pu; Jianpeng Xue; Sebastião Pratavieira; Baogang Xu; Samuel Achilefu; Robert R. Alfano
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Paper Abstract

Tryptophan is investigated as the key native marker in cells to determine the level of metastasis competence in breast cell lines using native fluorescence spectroscopy. The ratio of fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. We found that the fluorescence of aggressive breast cancer cell has a much higher contribution from tryptophan compared with that from the normal cells and nonaggressive breast cancer cell.

Paper Details

Date Published: 27 March 2014
PDF: 6 pages
J. Biomed. Opt. 19(3) 037005 doi: 10.1117/1.JBO.19.3.037005
Published in: Journal of Biomedical Optics Volume 19, Issue 3
Show Author Affiliations
Lin Zhang, The City College of New York (United States)
Yang Pu, The City College of New York (United States)
Jianpeng Xue, Washington Univ. School of Medicine in St. Louis (United States)
Sebastião Pratavieira, Univ. de São Paulo (Brazil)
Baogang Xu, Washington Univ. School of Medicine in St. Louis (United States)
Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (United States)
Robert R. Alfano, The City College of New York (United States)


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