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Journal of Biomedical Optics • Open Access

Light path-length distributions within the retina
Author(s): Paul I. Rodmell; John A. Crowe; Alistair Gorman; Andrew R. Harvey; Gonzalo Muyo; David J. Mordant; Andrew I. McNaught; Stephen P. Morgan

Paper Abstract

A Monte Carlo simulation of light propagation through the retina has been developed to understand the path-length distributions within the retinal vessel. For full-field illumination, the path-length distribution within the vessel comprises directly backscattered light and light that has passed once or twice through the vessel. The origins of these light path-length distributions can be better understood by investigating different combinations of single-point illumination and detection positions. Perhaps the most significant observation is that illumination at the edges of the vessel, rather than over the whole field of view, and detection directly above the vessel capture only the light that has taken a single pass through the vessel. This path-length distribution is tightly constrained around the diameter of the vessel and can potentially provide enhancements for oxygen saturation imaging. The method could be practically implemented using an offset-pinhole confocal imaging system or structured light illumination.

Paper Details

Date Published: 10 March 2014
PDF: 9 pages
J. Biomed. Opt. 19(3) 036008 doi: 10.1117/1.JBO.19.3.036008
Published in: Journal of Biomedical Optics Volume 19, Issue 3
Show Author Affiliations
Paul I. Rodmell, The Univ. of Nottingham (United Kingdom)
John A. Crowe, The Univ. of Nottingham (United Kingdom)
Alistair Gorman, Univ. of Glasgow (United Kingdom)
Andrew R. Harvey, Univ. of Glasgow (United Kingdom)
Gonzalo Muyo, Heriot-Watt Univ. (United Kingdom)
David J. Mordant, Cheltenham General Hospital (United Kingdom)
Andrew I. McNaught, Cheltenham General Hospital (United Kingdom)
Stephen P. Morgan, The Univ. of Nottingham (United Kingdom)


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