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Journal of Biomedical Optics • Open Access

Targeted zwitterionic near infrared fluorescent probe for improved imaging of type 2 cannabinoid receptors
Author(s): Zhiyuan Wu; Pin Shao; Shaojuan Zhang; Mingfeng Bai

Paper Abstract

Recent studies indicate that the type 2 cannabinoid receptors (CB 2 R ) have become an attractive target for treating a variety of pathologies, including cancers, neurodegenerative diseases, inflammation, pain, osteoporosis, immunological disorders and drug abuse. In addition, it appears that many of these diseases have up-regulated CB 2 R expression. However, the precise role of CB 2 R in the regulation of diseases remains unclear. The ability to specifically image CB 2 R would contribute to develop reliable CB 2 R -based therapeutic approaches with a better understanding of the mechanism of CB 2 R action in these diseases. We developed a CB 2 R -targeted zwitterionic near-infrared (NIR) fluorescent probe, ZW760-mbc94. When compared with a previously reported CB 2 R probe (NIR760-mbc94) with the same targeting moiety but a charged NIR fluorescent dye, ZW760-mbc94 showed improved binding specificity in vitro and ex vivo. Overall, ZW760-mbc94 appears to have great potential as a CB 2 R -targeted contrast agent.

Paper Details

Date Published: 6 March 2014
PDF: 11 pages
J. Biomed. Opt. 19(3) 036006 doi: 10.1117/1.JBO.19.3.036006
Published in: Journal of Biomedical Optics Volume 19, Issue 3
Show Author Affiliations
Zhiyuan Wu, Univ. of Pittsburgh (United States)
Pin Shao, Univ. of Pittsburgh (United States)
Shaojuan Zhang, Univ. of Pittsburgh (United States)
Mingfeng Bai, Univ. of Pittsburgh (United States)

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