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Journal of Biomedical Optics • Open Access

Photopolymerizable hydrogels for implants: Monte-Carlo modeling and experimental in vitro validation
Author(s): Andreas Schmocker; Azadeh Khoushabi; Constantin Schizas; Pierre-Etienne Bourban; Dominique Pioletti; Christophe Moser

Paper Abstract

Photopolymerization is commonly used in a broad range of bioapplications, such as drug delivery, tissue engineering, and surgical implants, where liquid materials are injected and then hardened by means of illumination to create a solid polymer network. However, photopolymerization using a probe, e.g., needle guiding both the liquid and the curing illumination, has not been thoroughly investigated. We present a Monte Carlo model that takes into account the dynamic absorption and scattering parameters as well as solid–liquid boundaries of the photopolymer to yield the shape and volume of minimally invasively injected, photopolymerized hydrogels. In the first part of the article, our model is validated using a set of well-known poly(ethylene glycol) dimethacrylate hydrogels showing an excellent agreement between simulated and experimental volume-growth-rates. In the second part, in situ experimental results and simulations for photopolymerization in tissue cavities are presented. It was found that a cavity with a volume of 152  mm 3 can be photopolymerized from the output of a 0.28-mm 2 fiber by adding scattering lipid particles while only a volume of 38  mm 3 (25%) was achieved without particles. The proposed model provides a simple and robust method to solve complex photopolymerization problems, where the dimension of the light source is much smaller than the volume of the photopolymerizable hydrogel.

Paper Details

Date Published: 10 March 2014
PDF: 8 pages
J. Biomed. Opt. 19(3) 035004 doi: 10.1117/1.JBO.19.3.035004
Published in: Journal of Biomedical Optics Volume 19, Issue 3
Show Author Affiliations
Andreas Schmocker, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Azadeh Khoushabi, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Constantin Schizas, Ctr. Hospitalier Univ. Vaudois (Switzerland)
Pierre-Etienne Bourban, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Dominique Pioletti, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Christophe Moser, Ecole Polytechnique Fédérale de Lausanne (Switzerland)

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