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Journal of Biomedical Optics • Open Access

Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography

Paper Abstract

In this study, polarization-sensitive optical coherence tomography (PS-OCT) capable of providing polarization contrasts such as phase retardation and degree of polarization uniformity (DOPU) was used for visualizing human meibomian glands (MGs) and investigating morphological characteristics of them. Especially, with the help of the DOPU contrast, MGs were exclusively extracted from the volumetric OCT image. In vivo PS-OCT measurements were performed on the upper eyelids of different age groups. From these measurements, different age-dependent aspects of the MG structure were also observed. Based on these observations, it can be inferred that the PS-OCT system has the potential for clinical diagnosis and investigation of MG-related dry eye diseases like MG dysfunction (MGD) and acinar atrophy.

Paper Details

Date Published: 6 March 2014
PDF: 4 pages
J. Biomed. Opt. 19(3) 030503 doi: 10.1117/1.JBO.19.3.030503
Published in: Journal of Biomedical Optics Volume 19, Issue 3
Show Author Affiliations
Myeong Jin Ju, The Univ. of British Columbia (Canada)
Jun Geun Shin, Gwangju Institute of Science and Technology (Korea, Republic of)
Sujin Hoshi, Univ. of Tsukuba (Japan)
Yoshiaki Yasuno, Univ. of Tsukuba (Japan)
Byeong Ha Lee, Gwangju Institute of Science and Technology (Korea, Republic of)
Shuo Tang, The Univ. of British Columbia (Canada)
Tae Joong Eom, Gwangju Institute of Science and Technology (Korea, Republic of)

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