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Journal of Biomedical Optics • Open Access

Correlation between asymmetry of spontaneous oscillation of hemodynamic changes in the prefrontal cortex and anxiety levels: a near-infrared spectroscopy study
Author(s): Wakana Ishikawa; Masakaze Sato; Yukikatsu Fukuda; Takashi Matsumoto; Naohiro Matsumoto; Kaoru Sakatani

Paper Abstract

According to the valence asymmetry hypothesis, the left/right asymmetry of prefrontal cortex (PFC) activity is correlated with specific emotional responses to mental stress and personality traits. Here, we evaluated the relation between emotional state and asymmetry in PFC activity at rest by using near-infrared spectroscopy (NIRS). We measured spontaneous oscillation of oxyhemoglobin (oxy-Hb) concentrations in the bilateral PFC at rest in normal adults employing two-channel NIRS. In order to analyze left/right asymmetry of PFC activity at rest, we calculated the laterality index at rest (LIR) (see text). We investigated the correlation between the LIR and anxiety levels evaluated by the State-Trait Anxiety Inventory (STAI) test. We found that the right PFC was more active at rest than the left PFC, corresponding to a higher anxiety level measured by the STAI; that is, subjects with right-dominant activity at rest showed higher STAI scores, while those with left-dominant oxy-Hb changes at rest showed lower STAI scores. Aging had no significant effect on the relation. The present results obtained by NIRS are consistent with the valence asymmetry hypothesis. We emphasize NIRS may be a useful tool for objective assessment of anxiety levels.

Paper Details

Date Published: 18 February 2014
PDF: 8 pages
J. Biomed. Opt. 19(2) 027005 doi: 10.1117/1.JBO.19.2.027005
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Wakana Ishikawa, Waseda Univ. (Japan)
Masakaze Sato, Waseda Univ. (Japan)
Yukikatsu Fukuda, Waseda Univ. (Japan)
Takashi Matsumoto, Waseda Univ. (Japan)
Naohiro Matsumoto, Nihon Univ. (Japan)
Kaoru Sakatani, Nihon Univ. School of Medicine (Japan)

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