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Journal of Biomedical Optics

New method for remote and repeatable monitoring of intraocular pressure variations
Author(s): Israel Margalit; Yevgeny Beiderman; Alon Skaat; Elkana Rosenfeld; Michael Belkin; Ralf-Peter Tornow; Vicente Mico; Javier Garcia; Zeev Zalevsky
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Paper Abstract

We present initial steps toward a new measurement device enabling high-precision, noncontact remote and repeatable monitoring of intraocular pressure (IOP)-based on an innovative measurement principle. Using only a camera and a laser source, the device measures IOP by tracking the secondary speckle pattern trajectories produced by the reflection of an illuminating laser beam from the iris or the sclera. The device was tested on rabbit eyes using two different methods to modify IOP: via an infusion bag and via mechanical pressure. In both cases, the eyes were stimulated with increasing and decreasing ramps of the IOP. As IOP variations changed the speckle distributions reflected back from the eye, data were recorded under various optical configurations to define and optimize the best experimental configuration for the IOP extraction. The association between the data provided by our proposed device and that resulting from controlled modification of the IOP was assessed, revealing high correlation (R2 =0.98 ) and sensitivity and providing a high-precision measurement (5% estimated error) for the best experimental configuration. Future steps will be directed toward applying the proposed measurement principle in clinical trials for monitoring IOP with human subjects.

Paper Details

Date Published: 6 February 2014
PDF: 9 pages
J. Biomed. Opt. 19(2) 027002 doi: 10.1117/1.JBO.19.2.027002
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Israel Margalit, Bar-Ilan Univ. (Israel)
Yevgeny Beiderman, Bar-Ilan Univ. (Israel)
Alon Skaat, Tel Aviv Univ. (Israel)
Elkana Rosenfeld, Tel Aviv Univ. (Israel)
Michael Belkin, Tel Aviv Univ. (Israel)
Ralf-Peter Tornow, Universitätsklinikum Erlangen (Germany)
Vicente Mico, Univ. de València (Spain)
Javier Garcia, Univ. de València (Spain)
Zeev Zalevsky, Bar-Ilan Univ. (Israel)

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