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Journal of Biomedical Optics

Anthropomorphic breast phantoms with physiological water, lipid, and hemoglobin content for near-infrared spectral tomography
Author(s): Kelly E. Michaelsen; Venkataramanan Krishnaswamy; Adele Shenoy; Emily Jordan; Brian W. Pogue; Keith D. Paulsen
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Paper Abstract

Breast mimicking tissue optical phantoms with sufficient structural integrity to be deployed as stand-alone imaging targets are developed and successfully constructed with biologically relevant concentrations of water, lipid, and blood. The results show excellent material homogeneity and reproducibility with inter- and intraphantom variability of 3.5 and 3.8%, respectively, for water and lipid concentrations ranging from 15 to 85%. The phantoms were long-lasting and exhibited water and lipid fractions that were consistent to within 5% of their original content when measured 2 weeks after creation. A breast-shaped three-compartment model of adipose, fibroglandular, and malignant tissues was created with water content ranging from 30% for the adipose simulant to 80% for the tumor. Mean measured water content ranged from 30% in simulated adipose to 73% in simulated tumor with the higher water localized to the tumor-like material. This novel heterogeneous phantom design is composed of physiologically relevant concentrations of the major optical absorbers in the breast in the near-infrared wavelengths that should significantly improve imaging system characterization and optimization because the materials have stand-alone structural integrity and can be readily molded into the sizes and shapes of tissues commensurate with clinical breast imaging.

Paper Details

Date Published: 18 February 2014
PDF: 9 pages
J. Biomed. Opt. 19(2) 026012 doi: 10.1117/1.JBO.19.2.026012
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Kelly E. Michaelsen, Thayer School of Engineering at Dartmouth (United States)
Venkataramanan Krishnaswamy, Thayer School of Engineering at Dartmouth (United States)
Adele Shenoy, Thayer School of Engineering at Dartmouth (United States)
Emily Jordan, Thayer School of Engineering at Dartmouth (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Keith D. Paulsen, Thayer School of Engineering at Dartmouth (United States)

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