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Journal of Biomedical Optics

Methodology for fully automated segmentation and plaque characterization in intracoronary optical coherence tomography images
Author(s): Lambros S. Athanasiou; Christos V. Bourantas; George Rigas; Antonis I. Sakellarios; Themis P. Exarchos; Panagiotis K. Siogkas; Andrea Ricciardi; Katerina K. Naka; Michail I. Papafaklis; Lampros K. Michalis; Francesco Prati; Dimitrios I. Fotiadis
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Paper Abstract

Optical coherence tomography (OCT) is a light-based intracoronary imaging modality that provides high-resolution cross-sectional images of the luminal and plaque morphology. Currently, the segmentation of OCT images and identification of the composition of plaque are mainly performed manually by expert observers. However, this process is laborious and time consuming and its accuracy relies on the expertise of the observer. To address these limitations, we present a methodology that is able to process the OCT data in a fully automated fashion. The proposed methodology is able to detect the lumen borders in the OCT frames, identify the plaque region, and detect four tissue types: calcium (CA), lipid tissue (LT), fibrous tissue (FT), and mixed tissue (MT). The efficiency of the developed methodology was evaluated using annotations from 27 OCT pullbacks acquired from 22 patients. High Pearson’s correlation coefficients were obtained between the output of the developed methodology and the manual annotations (from 0.96 to 0.99), while no significant bias with good limits of agreement was shown in the Bland-Altman analysis. The overlapping areas ratio between experts’ annotations and methodology in detecting CA, LT, FT, and MT was 0.81, 0.71, 0.87, and 0.81, respectively.

Paper Details

Date Published: 13 February 2014
PDF: 14 pages
J. Biomed. Opt. 19(2) 026009 doi: 10.1117/1.JBO.19.2.026009
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Lambros S. Athanasiou, Univ. of Ioannina (Greece)
Christos V. Bourantas, Erasmus MC (Netherlands)
George Rigas, Univ. of Ioannina (Greece)
Antonis I. Sakellarios, Univ. of Ioannina (Greece)
Themis P. Exarchos, Univ. of Ioannina (Greece)
Panagiotis K. Siogkas, Univ. of Ioannina (Greece)
Andrea Ricciardi, Ettore Sansavini Health Science Foundation (Italy)
Katerina K. Naka, Univ. of Ioannina (Greece)
Michail I. Papafaklis, Brigham and Women's Hospital (United States)
Lampros K. Michalis, Univ. of Ioannina (Greece)
Francesco Prati, San Giovanni Hospital (Italy)
Dimitrios I. Fotiadis, Univ. of Ioannina (Greece)

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