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Journal of Biomedical Optics

Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study
Author(s): Michele L. Pierro; Jana M. Kainerstorfer; Amanda Civiletto; Daniel E. Weiner; Angelo Sassaroli; Bertan Hallacoglu; Sergio Fantini
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Paper Abstract

We present a pilot clinical application of coherent hemodynamics spectroscopy (CHS), a technique to investigate cerebral hemodynamics at the microcirculatory level. CHS relies on frequency-resolved measurements of induced cerebral hemodynamic oscillations that are measured with near-infrared spectroscopy (NIRS) and analyzed with a hemodynamic model. We have used cyclic inflation (200 mmHg) and deflation of a pneumatic cuff placed around the subject’s thigh at seven frequencies in the range of 0.03 to 0.17 Hz to generate CHS spectra and to obtain a set of physiological parameters that include the blood transit times in the cerebral microcirculation, the cutoff frequency for cerebral autoregulation, and blood volume ratios across the three different compartments. We have investigated five hemodialysis patients, during the hemodialysis procedure, and six healthy subjects. We have found that the blood transit time in the cerebral microcirculation is significantly longer in hemodialysis patients with respect to healthy subjects. No significant differences were observed between the two groups in terms of autoregulation efficiency and blood volume ratios. The demonstration of the applicability of CHS in a clinical setting and its sensitivity to the highly important cerebral microcirculation may open up new opportunities for NIRS applications in research and in medical diagnostics and monitoring.

Paper Details

Date Published: 12 February 2014
PDF: 10 pages
J. Biomed. Opt. 19(2) 026005 doi: 10.1117/1.JBO.19.2.026005
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Michele L. Pierro, Tufts Univ. (United States)
Jana M. Kainerstorfer, Tufts Univ. (United States)
Amanda Civiletto, Tufts Medical Ctr. (United States)
Daniel E. Weiner, Tufts Medical Ctr. (United States)
Angelo Sassaroli, Tufts Univ. (United States)
Bertan Hallacoglu, Tufts Univ. (United States)
Sergio Fantini, Tufts Univ. (United States)

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