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Journal of Biomedical Optics

Extension of the GATE Monte-Carlo simulation package to model bioluminescence and fluorescence imaging
Author(s): Vesna Cuplov; Irene Buvat; Frederic Pain; Sebastien Jan
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Paper Abstract

The Geant4 Application for Emission Tomography (GATE) is an advanced open-source software dedicated to Monte-Carlo (MC) simulations in medical imaging involving photon transportation (Positron emission tomography, single photon emission computed tomography, computed tomography) and in particle therapy. In this work, we extend the GATE to support simulations of optical imaging, such as bioluminescence or fluorescence imaging, and validate it against the MC for multilayered media standard simulation tool for biomedical optics in simple geometries. A full simulation set-up for molecular optical imaging (bioluminescence and fluorescence) is implemented in GATE, and images of the light distribution emitted from a phantom demonstrate the relevance of using GATE for optical imaging simulations.

Paper Details

Date Published: 12 February 2014
PDF: 13 pages
J. Biomed. Opt. 19(2) 026004 doi: 10.1117/1.JBO.19.2.026004
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Vesna Cuplov, Service Hospitalier Frédéric Joliot (France)
Irene Buvat, Univ. Paris-Sud 11 (France)
Frederic Pain, Univ. Paris-Sud 11 (France)
Sebastien Jan, Service Hospitalier Frédéric Joliot (France)

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