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Journal of Biomedical Optics

Photoacoustic thermography of tissue
Author(s): Haixin Ke; Stephen Tai; Lihong V. Wang
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Paper Abstract

Photoacoustic (PA) techniques can measure temperature in biological tissues because PA signal amplitude is sensitive to tissue temperature. So far, temperature-measuring PA techniques have focused on sensing of temperature changes at a single position. In this work, we photoacoustically measured spatial distribution of temperature in deep tissue. By monitoring the temperature at a single position using a thermocouple, the relationship between the PA signal amplitude and the actual temperature was determined. The relationship was then used to translate a PA image into a temperature map. This study showed that it is possible to calibrate the system for the temperature range of hyperthermia using single-point measurements over a smaller temperature range. Our experimental results showed a precision of −0.8±0.4°C (mean±standard error ) in temperature measurement, and a spatial resolution as fine as 1.0 mm. PA techniques can be potentially applied to monitor temperature distribution deep in tissue during hyperthermia treatment of cancer.

Paper Details

Date Published: 12 February 2014
PDF: 5 pages
J. Biomed. Opt. 19(2) 026003 doi: 10.1117/1.JBO.19.2.026003
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Haixin Ke, Washington Univ. in St. Louis (United States)
Stephen Tai, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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