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Journal of Biomedical Optics • Open Access

Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit
Author(s): Jing Xu; Kevin Wong; Yifan Jian; Marinko V. Sarunic

Paper Abstract

In this report, we describe a graphics processing unit (GPU)-accelerated processing platform for real-time acquisition and display of flow contrast images with Fourier domain optical coherence tomography (FDOCT) in mouse and human eyes in vivo. Motion contrast from blood flow is processed using the speckle variance OCT (svOCT) technique, which relies on the acquisition of multiple B-scan frames at the same location and tracking the change of the speckle pattern. Real-time mouse and human retinal imaging using two different custom-built OCT systems with processing and display performed on GPU are presented with an in-depth analysis of performance metrics. The display output included structural OCT data, en face projections of the intensity data, and the svOCT en face projections of retinal microvasculature; these results compare projections with and without speckle variance in the different retinal layers to reveal significant contrast improvements. As a demonstration, videos of real-time svOCT for in vivo human and mouse retinal imaging are included in our results. The capability of performing real-time svOCT imaging of the retinal vasculature may be a useful tool in a clinical environment for monitoring disease-related pathological changes in the microcirculation such as diabetic retinopathy.

Paper Details

Date Published: 6 February 2014
PDF: 6 pages
J. Biomed. Opt. 19(2) 026001 doi: 10.1117/1.JBO.19.2.026001
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Jing Xu, Simon Fraser Univ. (Canada)
Kevin Wong, Simon Fraser Univ. (Canada)
Yifan Jian, Simon Fraser Univ. (Canada)
Marinko V. Sarunic, Simon Fraser Univ. (Canada)


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