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Journal of Biomedical Optics • Open Access

Retina-simulating phantom for optical coherence tomography
Author(s): Jigesh Baxi; William R. Calhoun; Yasir J. Sepah; Daniel X. Hammer; Ilko Ilev; T. Joshua Pfefer; Quan Dong Nguyen; Anant Agrawal

Paper Abstract

Optical coherence tomography (OCT) is a rapidly growing imaging modality, particularly in the field of ophthalmology. Accurate early diagnosis of diseases requires consistent and validated imaging performance. In contrast to more well-established medical imaging modalities, no standardized test methods currently exist for OCT quality assurance. We developed a retinal phantom which mimics the thickness and near-infrared optical properties of each anatomical retinal layer as well as the surface topography of the foveal pit. The fabrication process involves layer-by-layer spin coating of nanoparticle-embedded silicone films followed by laser micro-etching to modify the surface topography. The thickness of each layer and dimensions of the foveal pit are measured with high precision. The phantom is embedded into a commercially available, water-filled model eye to simulate ocular dispersion and emmetropic refraction, and for ease of use with clinical OCT systems. The phantom was imaged with research and clinical OCT systems to assess image quality and software accuracy. Our results indicate that this phantom may serve as a useful tool to evaluate and standardize OCT performance.

Paper Details

Date Published: 16 September 2013
PDF: 9 pages
J. Biomed. Opt. 19(2) 021106 doi: 10.1117/1.JBO.19.2.021106
Published in: Journal of Biomedical Optics Volume 19, Issue 2
Show Author Affiliations
Jigesh Baxi, U.S. Food and Drug Administration (United States)
William R. Calhoun, U.S. Food and Drug Administration (United States)
Yasir J. Sepah, Wilmer Eye Institute (United States)
Daniel X. Hammer, U.S. Food and Drug Administration (United States)
Ilko Ilev, U.S. Food and Drug Administration (United States)
T. Joshua Pfefer, U.S. Food and Drug Administration (United States)
Quan Dong Nguyen, Wilmer Eye Institute (United States)
Anant Agrawal, U.S. Food and Drug Administration (United States)

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