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Journal of Biomedical Optics

Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
Author(s): Peijun Gong; Lixin Chin; Shaghayegh Es’haghian; Yih Miin Liew; Fiona M. Wood; David D. Sampson; Robert A. McLaughlin
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Paper Abstract

We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artifacts, we preprocessed the PS-OCT data using a vascular masking technique. The birefringence of the remaining tissue regions was then automatically quantified. Results from the scars and contralateral or adjacent normal skin of 13 patients show a correspondence of birefringence with scar type: the ratio of birefringence of hypertrophic scars to corresponding normal skin is 2.2±0.2 (mean±standard deviation), while the ratio of birefringence of normotrophic scars to normal skin is 1.1±0.4. This method represents a new clinically applicable means for objective, quantitative human scar assessment.

Paper Details

Date Published: 24 December 2014
PDF: 9 pages
J. Biomed. Opt. 19(12) 126014 doi: 10.1117/1.JBO.19.12.126014
Published in: Journal of Biomedical Optics Volume 19, Issue 12
Show Author Affiliations
Peijun Gong, The Univ. of Western Australia (Australia)
Lixin Chin, The Univ. of Western Australia (Australia)
Shaghayegh Es’haghian, The Univ. of Western Australia (Australia)
Yih Miin Liew, Univ. of Malaya (Malaysia)
Fiona M. Wood, Royal Perth Hospital (Australia)
The Univ. of Western Australia (Australia)
David D. Sampson, The Univ. of Western Australia (Australia)
Robert A. McLaughlin, The Univ. of Western Australia (Australia)


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