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Journal of Biomedical Optics • Open Access

<italic<In vivo</italic< visualization of prostate brachytherapy seeds with photoacoustic imaging
Author(s): Muyinatu A. Lediju Bell; Nathanael P. Kuo; Danny Y. Song; Jin U. Kang; Emad M. Boctor

Paper Abstract

We conducted a canine study to investigate the <italic<in vivo</italic< feasibility of photoacoustic imaging for intraoperative updates to brachytherapy treatment plans. A fiber coupled to a 1064-nm Nd:YAG laser was inserted into high-dose-rate brachytherapy needles, which diffused light spherically. These needles were inserted through the perineum into the prostate for interstitial light delivery and the resulting acoustic waves were detected with a transrectal ultrasound probe. Postoperative computed tomography images and <italic<ex vivo</italic< photoacoustic images confirmed seed locations. Limitations with insufficient light delivery were mitigated with short-lag spatial coherence (SLSC) beamforming, providing a 10–20 dB contrast improvement over delay-and-sum (DAS) beamforming for pulse energies ranging from 6.8 to 10.5 mJ with a fiber-seed distance as large as 9.5 mm. For the same distance and the same range of energy densities, signal-to-noise ratios (SNRs) were similar while the contrast-to-noise ratio (CNR) was higher in SLSC compared to DAS images. Challenges included visualization of signals associated with the interstitial fiber tip and acoustic reverberations between seeds separated by ≤2 mm. Results provide insights into the potential for clinical translation to humans.

Paper Details

Date Published: 22 December 2014
PDF: 13 pages
J. Biomed. Opt. 19(12) 126011 doi: 10.1117/1.JBO.19.12.126011
Published in: Journal of Biomedical Optics Volume 19, Issue 12
Show Author Affiliations
Muyinatu A. Lediju Bell, Johns Hopkins Univ. (United States)
Nathanael P. Kuo, Johns Hopkins Univ. (United States)
Danny Y. Song, Johns Hopkins Univ. (United States)
Jin U. Kang, Johns Hopkins Univ. (United States)
Emad M. Boctor, Johns Hopkins Univ. (United States)

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