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Journal of Biomedical Optics

Laser-induced microjet injection into preablated skin for more effective transdermal drug delivery
Author(s): Hun-Jae Jang; Eugene Hur; Yoonkwan Kim; Seol-Hoon Lee; Naegyu Kang; Jack J. Yoh
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Paper Abstract

A breakthrough in the efficient transdermal delivery of drug via the laser-driven microjet is reported. A single source of laser beam is split into two: one beam ablates a targeted spot on a skin and another beam drives the injector for fast microjet ejection into a preablated spot. This combined ablation and microjet injection scheme using a beam splitter utilizes 1∶4 laser energy sharing between generation of the microhole via ablation and the microjet which is generated using the Er:YAG laser beam at a 2940-nm wavelength and 150-μs pulse duration. A careful analysis of the injection mechanism is carried out by studying the response of the elastic membrane that separates a driving water unit for bubble expansion from a drug unit for a microjet ejection. The efficiency of the present delivery scheme is evaluated by the abdominal porcine skin test using the fluorescein isothiocyanate staining and the confocal microscopy for quantitative delivery confirmation. The depth of penetration and the injected volume of the drug are also confirmed by polyacrylamide gel tests.

Paper Details

Date Published: 18 November 2014
PDF: 7 pages
J. Biomed. Opt. 19(11) 118002 doi: 10.1117/1.JBO.19.11.118002
Published in: Journal of Biomedical Optics Volume 19, Issue 11
Show Author Affiliations
Hun-Jae Jang, Seoul National Univ. (Republic of Korea)
Eugene Hur, LG Household & Health Care, Ltd. (Republic of Korea)
Yoonkwan Kim, LG Household & Health Care, Ltd. (Republic of Korea)
Seol-Hoon Lee, LG Household & Health Care, Ltd. (Republic of Korea)
Naegyu Kang, LG Household & Health Care, Ltd. (Republic of Korea)
Jack J. Yoh, Seoul National University (Republic of Korea)

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