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Journal of Biomedical Optics

Clinical study of noninvasive <italic<in vivo</italic< melanoma and nonmelanoma skin cancers using multimodal spectral diagnosis
Author(s): Liang Lim; Brandon S. Nichols; Michael R. Migden; Narasimhan Rajaram; Jason Reichenberg; Mia K. Markey; Merrick I. Ross; James W. Tunnell
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Paper Abstract

The goal of this study was to determine the diagnostic capability of a multimodal spectral diagnosis (SD) for <italic<in vivo</italic< noninvasive disease diagnosis of melanoma and nonmelanoma skin cancers. We acquired reflectance, fluorescence, and Raman spectra from 137 lesions in 76 patients using custom-built optical fiber-based clinical systems. Biopsies of lesions were classified using standard histopathology as malignant melanoma (MM), nonmelanoma pigmented lesion (PL), basal cell carcinoma (BCC), actinic keratosis (AK), and squamous cell carcinoma (SCC). Spectral data were analyzed using principal component analysis. Using multiple diagnostically relevant principal components, we built leave-one-out logistic regression classifiers. Classification results were compared with histopathology of the lesion. Sensitivity/specificity for classifying MM versus PL (12 versus 17 lesions) was 100%/100%, for SCC and BCC versus AK (57 versus 14 lesions) was 95%/71%, and for AK and SCC and BCC versus normal skin (71 versus 71 lesions) was 90%/85%. The best classification for nonmelanoma skin cancers required multiple modalities; however, the best melanoma classification occurred with Raman spectroscopy alone. The high diagnostic accuracy for classifying both melanoma and nonmelanoma skin cancer lesions demonstrates the potential for SD as a clinical diagnostic device.

Paper Details

Date Published: 6 November 2014
PDF: 12 pages
J. Biomed. Opt. 19(11) 117003 doi: 10.1117/1.JBO.19.11.117003
Published in: Journal of Biomedical Optics Volume 19, Issue 11
Show Author Affiliations
Liang Lim, The Univ. of Texas at Austin (United States)
Brandon S. Nichols, The Univ. of Texas at Austin (United States)
Michael R. Migden, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Narasimhan Rajaram, The Univ. of Texas at Austin (United States)
Jason Reichenberg, The Univ. of Texas at Austin (United States)
Mia K. Markey, The Univ. of Texas at Austin (United States)
Merrick I. Ross, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
James W. Tunnell, The Univ. of Texas at Austin (United States)

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