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Journal of Biomedical Optics • Open Access

Low coherence interferometry approach for aiding fine needle aspiration biopsies
Author(s): Ernest W. Chang; Joseph A. Gardecki; Martha B. Pitman; Eric Wilsterman; Ankit H. Patel; Guillermo J. Tearney; Nicusor V. Iftimia

Paper Abstract

We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

Paper Details

Date Published: 6 November 2014
PDF: 10 pages
J. Biomed. Opt. 19(11) 116005 doi: 10.1117/1.JBO.19.11.116005
Published in: Journal of Biomedical Optics Volume 19, Issue 11
Show Author Affiliations
Ernest W. Chang, Physical Sciences Inc. (United States)
Joseph A. Gardecki, Massachusetts General Hospital (United States)
Martha B. Pitman, Massachusetts General Hospital (United States)
Eric Wilsterman, Wellman Ctr. for Photomedicine (United States)
Ankit H. Patel, Physical Sciences Inc. (United States)
Guillermo J. Tearney, Wellman Ctr. for Photomedicine (United States)
Nicusor V. Iftimia, Physical Sciences Inc. (United States)


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