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Journal of Biomedical Optics

Super-resolution photoacoustic microscopy using photonic nanojets: a simulation study
Author(s): Paul Kumar Upputuri; Zhuo-Bin Wen; Zhenya Wu; Manojit Pramanik
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Paper Abstract

Optical resolution photoacoustic microscopy (ORPAM) is important for various biomedical applications, such as the study of cellular structures, microcirculation systems, and tumor angiogenesis. However, the lateral resolution of a conventional ORPAM is limited by optical diffraction. In this work, we report a simulation study to achieve subdiffraction-limited super-resolution in ORPAM using microspheres. Laser radiation is focused through a microsphere to generate a photonic nanojet, which provides the possibility to break the diffraction limit in ORPAM by reducing the size of the excitation volume. In our simulations using microspheres, we observed improvement in the lateral resolution up to ∼fourfold compared to conventional ORPAM. The method is simple, cost effective, and can provide far-field resolution. This approach may provide new opportunities for many biomedical imaging applications that require finer resolution.

Paper Details

Date Published: 3 November 2014
PDF: 7 pages
J. Biomed. Opt. 19(11) 116003 doi: 10.1117/1.JBO.19.11.116003
Published in: Journal of Biomedical Optics Volume 19, Issue 11
Show Author Affiliations
Paul Kumar Upputuri, Nanyang Technological Univ. (Singapore)
Zhuo-Bin Wen, Univ. of Electronic Science and Technology of China (China)
Zhenya Wu, Univ. of Electronic Science and Technology of China (China)
Manojit Pramanik, Nanyang Technological Univ. (Singapore)

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