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Journal of Biomedical Optics • Open Access

Photoacoustic imaging of carotid artery atherosclerosis
Author(s): Pieter Kruizinga; Antonius F. W. van der Steen; Nico de Jong; Geert Springeling; Jan Lukas Robertus; Aad van der Lugt; Gijs van Soest

Paper Abstract

We introduce a method for photoacoustic imaging of the carotid artery, tailored toward detection of lipid-rich atherosclerotic lesions. A common human carotid artery was obtained at autopsy, embedded in a neck mimicking phantom and imaged with a multimodality imaging system using interstitial illumination. Light was delivered through a 1.25-mm-diameter optical probe that can be placed in the pharynx, allowing the carotid artery to be illuminated from within the body. Ultrasound imaging and photoacoustic signal detection is achieved by an external 8-MHz linear array coupled to an ultrasound imaging system. Spectroscopic analysis of photoacoustic images obtained in the wavelength range from 1130 to 1250 nm revealed plaque-specific lipid accumulation in the collagen structure of the artery wall. These spectroscopic findings were confirmed by histology.

Paper Details

Date Published: 21 November 2014
PDF: 3 pages
J. Biomed. Opt. 19(11) 110504 doi: 10.1117/1.JBO.19.11.110504
Published in: Journal of Biomedical Optics Volume 19, Issue 11
Show Author Affiliations
Pieter Kruizinga, Erasmus MC (The Netherlands)
Antonius F. W. van der Steen, Erasmus MC (The Netherlands)
Delft University of Technology (The Netherlands)
Interuniversity Cardiology Institute of The Netherlands (The Netherlands)
Nico de Jong, Erasmus MC (The Netherlands)
Delft University of Technology (The Netherlands)
Interuniversity Cardiology Institute of The Netherlands (The Netherlands)
Geert Springeling, Erasmus MC (The Netherlands)
Jan Lukas Robertus, Erasmus MC (The Netherlands)
Aad van der Lugt, Erasmus MC (The Netherlands)
Gijs van Soest, Erasmus MC (The Netherlands)


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