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Journal of Biomedical Optics • Open Access

Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography
Author(s): Dolonchampa Maji; Metasebya Solomon; Annie Nguyen; Richard A. Pierce; Pamela K. Woodard; Walter J. Akers; Samuel Achilefu; Joseph P. Culver; Dana R. Abendschein; Monica Shokeen

Paper Abstract

Insights into the etiology of stroke and myocardial infarction suggest that rupture of unstable atherosclerotic plaque is the precipitating event. Clinicians lack tools to detect lesion instability early enough to intervene, and are often left to manage patients empirically, or worse, after plaque rupture. Noninvasive imaging of the molecular events signaling prerupture plaque progression has the potential to reduce the morbidity and mortality associated with myocardial infarction and stroke by allowing early intervention. Here, we demonstrate proof-of-principle <italic<in vivo</italic< molecular imaging of C-type natriuretic peptide receptor in focal atherosclerotic lesions in the femoral arteries of New Zealand white rabbits using a custom built fiber-based, fluorescence molecular tomography (FMT) system. Longitudinal imaging showed changes in the fluorescence signal intensity as the plaque progressed in the air-desiccated vessel compared to the uninjured vessel, which was validated by <italic<ex vivo</italic< tissue studies. In summary, we demonstrate the potential of FMT for noninvasive detection of molecular events leading to unstable lesions heralding plaque rupture.

Paper Details

Date Published: 12 November 2014
PDF: 3 pages
J. Biomed. Opt. 19(11) 110501 doi: 10.1117/1.JBO.19.11.110501
Published in: Journal of Biomedical Optics Volume 19, Issue 11
Show Author Affiliations
Dolonchampa Maji, Washington Univ. School of Medicine in St. Louis (United States)
Washington Univ. in St. Louis (United States)
Metasebya Solomon, Washington Univ. in St. Louis (United States)
Washington Univ. School of Medicine St. Louis (United States)
Annie Nguyen, Washington Univ. School of Medicine in St. Louis (United States)
Richard A. Pierce, Washington Univ. School of Medicine in St. Louis (United States)
Pamela K. Woodard, Washington Univ. in St. Louis (United States)
Washington Univ. School of Medicine in St. Louis (United States)
Walter J. Akers, Washington Univ. School of Medicine in St. Louis (United States)
Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (United States)
Washington Univ. in St. Louis (United States)
Joseph P. Culver, Washington Univ. School of Medicine in St. Louis (United States)
Washington Univ. in St. Louis (United States)
Dana R. Abendschein, Washington Univ. School of Medicine in St. Louis (United States)
Monica Shokeen, Washington Univ. School of Medicine in St. Louis (United States)


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