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Journal of Biomedical Optics • Open Access

Optimal timing of retinal scanning during dark adaptation, in the presence of fixation on a target: the role of pupil size dynamics
Author(s): Boris I. Gramatikov; Kristina Irsch; David Guyton

Paper Abstract

While validating our newly developed vision screener based on a double-pass retinal scanning system, we noticed that in all patients the signals from the retina were significantly higher when measurements were performed within a certain time interval referenced to the initial moment when the lights were dimmed and the test subject was asked to fixate on a target. This appeared to be most likely attributable to pupil size dynamics and triggered the present study, whose aim was to assess the pupillary “lights-off” response while fixating on a target in the presence of an accommodative effort. We found that pupil size increases in the first 60 to 70 s after turning off the room lights, and then it decreases toward the baseline in an exponential decay. Our results suggest that there is an optimal time window during which pupil size is expected to be maximal, that is during the second minute after dimming the room lights. During this time, window retinal diagnostic instruments based on double-pass measurement technology should deliver an optimal signal-to-noise ratio. We also propose a mathematical model that can be used to approximate the behavior of the normalized pupil size.

Paper Details

Date Published: 27 October 2014
PDF: 3 pages
J. Biomed. Opt. 19(10) 106014 doi: 10.1117/1.JBO.19.10.106014
Published in: Journal of Biomedical Optics Volume 19, Issue 10
Show Author Affiliations
Boris I. Gramatikov, The Johns Hopkins Hospital (United States)
Kristina Irsch, The Johns Hopkins Hospital (United States)
David Guyton, The Johns Hopkins Hospital (United States)

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