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Journal of Biomedical Optics

Continuous monitoring of arthritis in animal models using optical imaging modalities
Author(s): Taeyoon Son; Hyung-Ju Yoon; Saseong Lee; Won Seuk Jang; Byungjo Jung; Wan-Uk Kim
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Paper Abstract

Given the several difficulties associated with histology, including difficulty in continuous monitoring, this study aimed to investigate the feasibility of optical imaging modalities—cross-polarization color (CPC) imaging, erythema index (EI) imaging, and laser speckle contrast (LSC) imaging—for continuous evaluation and monitoring of arthritis in animal models. C57BL/6 mice, used for the evaluation of arthritis, were divided into three groups: arthritic mice group (AMG), positive control mice group (PCMG), and negative control mice group (NCMG). Complete Freund’s adjuvant, mineral oil, and saline were injected into the footpad for AMG, PCMG, and NCMG, respectively. LSC and CPC images were acquired from 0 through 144 h after injection for all groups. EI images were calculated from CPC images. Variations in feet area, EI, and speckle index for each mice group over time were calculated for quantitative evaluation of arthritis. Histological examinations were performed, and the results were found to be consistent with those from optical imaging analysis. Thus, optical imaging modalities may be successfully applied for continuous evaluation and monitoring of arthritis in animal models.

Paper Details

Date Published: 23 October 2014
PDF: 7 pages
J. Biomed. Opt. 19(10) 106010 doi: 10.1117/1.JBO.19.10.106010
Published in: Journal of Biomedical Optics Volume 19, Issue 10
Show Author Affiliations
Taeyoon Son, Yonsei Univ. (Korea, Republic of)
Hyung-Ju Yoon, The Catholic Univ. of Korea (Korea, Republic of)
Saseong Lee, The Catholic Univ. of Korea (Korea, Republic of)
Won Seuk Jang, Yonsei Univ. (Korea, Republic of)
Byungjo Jung, Yonsei Univ. (Korea, Republic of)
Wan-Uk Kim, The Catholic Univ. of Korea (Korea, Republic of)


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