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Journal of Biomedical Optics

Inexpensive diffuse reflectance spectroscopy system for measuring changes in tissue optical properties
Author(s): Diana L. Glennie; Joseph E. Hayward; Daniel E. McKee; Thomas J. Farrell
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Paper Abstract

The measurement of changes in blood volume in tissue is important for monitoring the effects of a wide range of therapeutic interventions, from radiation therapy to skin-flap transplants. Many systems available for purchase are either expensive or difficult to use, limiting their utility in the clinical setting. A low-cost system, capable of measuring changes in tissue blood volume via diffuse reflectance spectroscopy is presented. The system consists of an integrating sphere coupled via optical fibers to a broadband light source and a spectrometer. Validation data are presented to illustrate the accuracy and reproducibility of the system. The validity and utility of this <italic<in vivo</italic< system were demonstrated in a skin blanching/reddening experiment using epinephrine and lidocaine, and in a study measuring the severity of radiation-induced erythema during radiation therapy.

Paper Details

Date Published: 7 October 2014
PDF: 7 pages
J. Biomed. Opt. 19(10) 105005 doi: 10.1117/1.JBO.19.10.105005
Published in: Journal of Biomedical Optics Volume 19, Issue 10
Show Author Affiliations
Diana L. Glennie, McMaster Univ. (Canada)
Joseph E. Hayward, McMaster Univ. (Canada)
Juravinski Cancer Ctr. (Canada)
Daniel E. McKee, McMaster Univ. (Canada)
Thomas J. Farrell, McMaster Univ. (Canada)
Juravinski Cancer Ctr. (Canada)

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