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Journal of Biomedical Optics • Open Access

Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke
Author(s): Peyman Zirak; Raquel Delgado-Mederos; Lavinia Dinia; David Carrera; Joan Martí-Fàbregas; Turgut Durduran

Paper Abstract

The ultimate goal of therapeutic strategies for ischemic stroke is to reestablish the blood flow to the ischemic region of the brain. However, currently, the local cerebral hemodynamics (microvascular) is almost entirely inaccessible for stroke clinicians at the patient bed-side, and the recanalization of the major cerebral arteries (macrovascular) is the only available measure to evaluate the therapy, which does not always reflect the local conditions. Here we report the case of an ischemic stroke patient whose microvascular cerebral blood flow and oxygenation were monitored by a compact hybrid diffuse optical monitor during thrombolytic therapy. This monitor combined diffuse correlation spectroscopy and near-infrared spectroscopy. The reperfusion assessed by hybrid diffuse optics temporally correlated with the recanalization of the middle cerebral artery (assessed by transcranial-Doppler) and was in agreement with the patient outcome. This study suggests that upon further investigation, diffuse optics might have a potential for bed-side acute stroke monitoring and therapy guidance by providing hemodynamics information at the microvascular level.

Paper Details

Date Published: 10 January 2014
PDF: 4 pages
J. Biomed. Opt. 19(1) 018002 doi: 10.1117/1.JBO.19.1.018002
Published in: Journal of Biomedical Optics Volume 19, Issue 1
Show Author Affiliations
Peyman Zirak, ICFO - Institut de Ciències Fotòniques (Spain)
Raquel Delgado-Mederos, Hospital de la Santa Creu i Sant Pau (Spain)
Lavinia Dinia, Hospital de la Santa Creu i Sant Pau (Spain)
David Carrera, Hospital de la Santa Creu i Sant Pau (Spain)
Joan Martí-Fàbregas, Hospital de la Santa Creu i Sant Pau (Spain)
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)


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