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Journal of Biomedical Optics • Open Access

Photoacoustic measurement of the Grüneisen parameter of tissue
Author(s): Da-Kang Yao; Chi Zhang; Konstantin I. Maslov; Lihong V. Wang

Paper Abstract

The Grüneisen parameter, a constitutive parameter in photoacoustics, is usually measured from isobaric thermal expansion, which may not be valid for a biological medium due to its heterogeneity. Here, we directly measured the Grüneisen parameter by applying photoacoustic spectroscopy. Laser pulses at wavelengths between 460 and 1800 nm were delivered to tissue samples, and photoacoustic signals were detected by flat water-immersion ultrasonic transducers. Least-squares fitting photoacoustic spectra to molar optical absorption spectra showed that the Grüneisen parameter was 0.81±0.05 (mean±SD ) for porcine subcutaneous fat tissue and 0.69±0.02 for porcine lipid at room temperature (22°C). The Grüneisen parameter of a red blood cell suspension was linearly related to hemoglobin concentration, and the parameter of bovine serum was 9% greater than that of water at room temperature.

Paper Details

Date Published: 28 January 2014
PDF: 8 pages
J. Biomed. Opt. 19(1) 017007 doi: 10.1117/1.JBO.19.1.017007
Published in: Journal of Biomedical Optics Volume 19, Issue 1
Show Author Affiliations
Da-Kang Yao, Washington Univ. in St. Louis (United States)
Chi Zhang, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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