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Journal of Biomedical Optics • Open Access

Correlation between skin, bone, and cerebrospinal fluid layer thickness and optical coefficients measured by multidistance frequency-domain near-infrared spectroscopy in term and preterm infants
Author(s): Anja Demel; Katharina Feilke; Martin Wolf; Christian F. Poets; Axel R. Franz

Paper Abstract

Near-infrared spectroscopy (NIRS) is increasingly used in neonatal intensive care. We investigated the impact of skin, bone, and cerebrospinal fluid (CSF) layer thickness in term and preterm infants on absorption-(μ a ) and/or reduced scattering coefficients (μ ′ s ) measured by multidistance frequency-domain (FD)-NIRS. Transcranial ultrasound was performed to measure the layer thicknesses. Correlations were only statistically significant for μ a at 692 nm with bone thickness and μ ′ s at 834 nm with skin thickness. There is no evidence that skin, bone, or CSF thickness have an important effect on μ a and μ ′ s . Layer thicknesses of skin, bone, and CSF in the range studied do not seem to affect cerebral oxygenation measurements by multidistance FD-NIRS significantly.

Paper Details

Date Published: 21 January 2014
PDF: 9 pages
J. Biomed. Opt. 19(1) 017004 doi: 10.1117/1.JBO.19.1.017004
Published in: Journal of Biomedical Optics Volume 19, Issue 1
Show Author Affiliations
Anja Demel, Univ. Children's Hospital Tuebingen (Germany)
Katharina Feilke, Univ. Children's Hospital Tuebingen (Germany)
Martin Wolf, Univ. Hospital Zürich (Switzerland)
Christian F. Poets, Univ. Children's Hospital Tuebingen (Germany)
Axel R. Franz, Univ. Children's Hospital Tuebingen (Germany)


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