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Journal of Biomedical Optics • Open Access

Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography
Author(s): Thu-Mai Nguyen; Shaozhen Song; Bastien Arnal; Emily Y. Wong; Zhihong Huang; Ruikang K. Wang; Matthew O'Donnell

Paper Abstract

Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (<12  dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.

Paper Details

Date Published: 17 January 2014
PDF: 7 pages
J. Biomed. Opt. 19(1) 016013 doi: 10.1117/1.JBO.19.1.016013
Published in: Journal of Biomedical Optics Volume 19, Issue 1
Show Author Affiliations
Thu-Mai Nguyen, Univ. of Washington (United States)
Shaozhen Song, Univ. of Washington (United States)
Bastien Arnal, Univ. of Washington (United States)
Emily Y. Wong, Univ. of Washington (United States)
Zhihong Huang, Univ. of Dundee (United Kingdom)
Ruikang K. Wang, Univ. of Washington (United States)
Matthew O'Donnell, Univ. of Washington (United States)

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